Second derivative spectrophotometric determination of cyclophosphamide in pharmaceutical formulations | Zendy

Amany Nabil | Zendy; Hemn A. Qader | Zendy; M. Naqishb Alaadin | Zendy

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Second derivative spectrophotometric determination of cyclophosphamide in pharmaceutical formulations

Author(s) -

Amany Nabil,

Hemn A. Qader,

M. Naqishb Alaadin

Publication year - 2013

Publication title -

african journal of biotechnology

Language(s) - English

Resource type - Journals

ISSN - 1684-5315

DOI - 10.5897/ajb12.2175

Subject(s) - derivative (finance) , chromatography , relative standard deviation , accuracy and precision , spectrophotometry , calibration curve , chemistry , second derivative , detection limit , correlation coefficient , dosage form , standard deviation , analytical chemistry (journal) , mathematics , statistics , mathematical analysis , financial economics , economics

A new, simple, rapid, wide applicable range and reliable second derivative spectrophotometric method has been developed for determination of cyclophosphamide (CP) in bulk and pharmaceutical dosage forms. Calibration graph is linear in the concentration range of 25 - 200 μg/ml of CP with 10 μg/ml of detection limit and correlation coefficient of 0.9976. The precision and accuracy were acceptable depending upon the values of relative standard deviation and error percentage. Developed second derivative spectrophotometric method can be directly and easily applied for analyzing pure form and commercial pharmaceutical preparations of CP. The method was compared with a standard high performance liquid chromatography (HPLC) method and can be used for the quality control of pharmaceutical preparations in Erbil City. Key words : Cyclophosphamide, derivative spectrophotometry.

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