Manumycin from a new Streptomyces strain shows antagonistic effect against methicillin-resistant Staphylococcus aureus (MRSA)/vancomycin-resistant enterococci (VRE) strains from Korean Hospitals | Zendy

Hee Choi Yun | Zendy; Sik Cho Seung | Zendy; Ram Simkhada Jaya | Zendy; Nam Seong | Zendy; Jeong Lee Hyo | Zendy; Seop Moon Hong | Zendy; Cheol Yoo Jin | Zendy

Open Access

Manumycin from a new Streptomyces strain shows antagonistic effect against methicillin-resistant Staphylococcus aureus (MRSA)/vancomycin-resistant enterococci (VRE) strains from Korean Hospitals

Author(s) -

Hee Choi Yun,

Sik Cho Seung,

Ram Simkhada Jaya,

Nam Seong,

Jeong Lee Hyo,

Seop Moon Hong,

Cheol Yoo Jin

Publication year - 2013

Publication title -

african journal of biotechnology

Language(s) - English

Resource type - Journals

ISSN - 1684-5315

DOI - 10.5897/ajb12.1501

Subject(s) - staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , vancomycin resistant enterococci , vancomycin , antimicrobial , enterococcus , strain (injury) , streptomyces , staphylococcus , bacteria , biology , antibiotics , genetics , anatomy

An antimicrobial compound, highly effective against multidrug-resistant (MDR) bacteria, purified from a Streptomyces strain was identified as manumycin. The minimal inhibitory concentrations (MICs) of manumycin against 8 different strains of methicillin-resistant Staphylococcus aureus (MRSA) were ranged 2 to 32 μg/ml. Similarly, MICs of manumycin against 4 vancomycin-resistant enterococci (VRE) strains were ranged 8 to 32 μg/ml while it remained ineffective against 4 other VRE strains. Compared to vancomycin, manumycin provided slightly weaker activity against MRSA strains but stronger activity against 4 VRE strains. This is the first report of antagonistic effect of manumycin against MDR pathogens. Keywords : Manumycin, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) African Journal of Biotechnology Vol. 12(17), pp. 2249-2253

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