Ethanol extract of Hedyotis diffusa willd. induction of apoptosis via PI3K/Akt and XIAP pathways in human leukemic THP-1 cells | Zendy

Wang He | Zendy; Zhou Yi Jun | Zendy; Yue Dong Mei | Zendy; Xue Bai | Zendy; He Ping | Zendy

Open Access

Ethanol extract of Hedyotis diffusa willd. induction of apoptosis via PI3K/Akt and XIAP pathways in human leukemic THP-1 cells

Author(s) -

Wang He,

Zhou Yi Jun,

Yue Dong Mei,

Xue Bai,

He Ping

Publication year - 2011

Publication title -

african journal of biotechnology

Language(s) - English

Resource type - Journals

ISSN - 1684-5315

DOI - 10.5897/ajb11.624

Subject(s) - xiap , apoptosis , thp1 cell line , pi3k/akt/mtor pathway , chemistry , protein kinase b , cancer cell , traditional medicine , caspase , pharmacology , cell culture , biology , biochemistry , cancer , programmed cell death , medicine , genetics

Hedyotis diffusa (H. diffusa) Willd. is known to induce apoptosis in cancer cells. However, the molecular mechanism of its anti-cancer activity has not been fully elucidated. In this study, we found that the ethanol extract of H. diffusa Willd. (EEHDW) reduced cell viability and induced apoptosis in a doseand time-dependent manner in human leukemic THP-1 cells. The induction of apoptosis was also accompanied by the down regulation of PI3K/Akt and the inhibitor of apoptosis protein (IAP) family proteins. Moreover, we observed that EEHDW treatment resulted in activation of caspase-3, which may partly explain the anti-cancer activity of EEHDW.

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