Immunogenicity of novel sulfadimethoxide conjugates | Zendy

Lei Chen | Zendy; Jianyu Su | Zendy; Zhang XiangZhai | Zendy; Lin Li | Zendy; HE Xiao-wei | Zendy

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Immunogenicity of novel sulfadimethoxide conjugates

Author(s) -

Lei Chen,

Jianyu Su,

Zhang XiangZhai,

Lin Li,

HE Xiao-wei

Publication year - 2011

Publication title -

african journal of biotechnology

Language(s) - English

Resource type - Journals

ISSN - 1684-5315

DOI - 10.5897/ajb10.2614

Subject(s) - sulfadimethoxine , immunogenicity , chemistry , antibody , sulfadiazine , enrofloxacin , conjugate , globulin , amylase , chromatography , antibiotics , biochemistry , biology , enzyme , immunology , mathematical analysis , mathematics , ciprofloxacin

Sulfadimethoxine (SDM) is an antibiotic commonly added to animal feeds. Anti-SDM antibodies are useful for the detection of residual SDM in foods, feeds and biological fluids by ELISA. In this study, we show that SDM is immunogenic in rabbits when it is conjugated with soy 11S globulin or with β- amylase. Rabbit anti-SDM antibodies obtained by immunization with SDM-11S and SDM-beta-amylase displayed low cross-reactivity against other sulfonamides, including sulfamethazine (SM2), sulfasulfonamides (SN), sulfadiazine (SD), sulfamethoxypyrazine (SMP), sulfalene (SMZ), sulfaquinoxaline (SQX). Thus, soy 11S globulin and β-amylase are suitable carriers for the induction of anti-SDM antibodies and have the advantage of being cheaper that BSA. Key words: Sulfadimethoxine (SDM), sulfasulfonamides (SN), sulfadiazine (SD), sulfamethazine (SM2), sulfamethoxypyrazine (SMP), sulfalene (SMZ), sulfaquinoxaline (SQX), rabbit anti-SDM antibodies, soy 11S globulin, SDM-beta-amylase.

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