In vivo activities of Baicalin against Chlamydia trachomatis | Zendy

Xiaojuan Qi | Zendy; Lei Fu | Zendy; Wen Su | Zendy; YoungSu Yi | Zendy; Ong | Zendy; Hao Huang | Zendy

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In vivo activities of Baicalin against Chlamydia trachomatis

Author(s) -

Xiaojuan Qi,

Lei Fu,

Wen Su,

YoungSu Yi,

Ong,

Hao Huang

Publication year - 2010

Publication title -

african journal of biotechnology

Language(s) - English

Resource type - Journals

ISSN - 1684-5315

DOI - 10.5897/ajb10.1713

Subject(s) - baicalin , chlamydia trachomatis , chlamydia , in vivo , microbiology and biotechnology , pathogen , medicine , biology , virology , chemistry , immunology , chromatography , high performance liquid chromatography

Our previous studies have shown that Baicalin could effectively inhibit Chlamydia trachomatis in vitro. In this study, Baicalin was tested for potential antichlamydial activity using a murine genital Chlamydia trachomatis infection model. It was demonstrated that Baicalin significantly reduced C. trachomatis loading in BALB/c mice that were vaginally infected with the pathogen. On the basis of these data and our previous observations, we concluded that further evaluation of Baicalin for prevention and treatment of sexually transmitted chlamydial infection is warranted.

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