Open AccessComparison of Human Papillomavirus RNA In Situ Hybridization and p16 Immunostaining in Diagnostically Challenging High-Grade Squamous Intraepithelial Lesions in the Background of Atrophy
Author(s) -
Natalie Banet,
Quanfu Mao,
Sharon Chu,
M. Ruhul Quddus
Publication year - 2022
Publication title -
archives of pathology and laboratory medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.79
H-Index - 117
eISSN - 1543-2165
pISSN - 0003-9985
DOI - 10.5858/arpa.2021-0426-oa
Subject(s) - in situ hybridization , pathology , squamous intraepithelial lesion , atrophy , immunostaining , medicine , cervix , immunohistochemistry , cancer , biology , cervical intraepithelial neoplasia , cervical cancer , messenger rna , gene , biochemistry
Human papillomavirus (HPV) in the postmenopausal age group is complex, with infected patients in this age group at increased risk of progressing to invasive disease and showing decreased clearance of the virus. Additionally, atrophic changes of the cervix can make histologic distinction of high-grade squamous intraepithelial lesions (HSILs) difficult.