Open AccessA Combination of MTAP and p16 Immunohistochemistry Can Substitute forCDKN2AFluorescence In Situ Hybridization in Diagnosis and Prognosis of Pleural Mesotheliomas
Author(s) -
Luka Brčić,
Nolwenn Le Stang,
Florian Gallob,
Daniel Pissaloux,
Ruth Sequeiros,
Sandrine Paindavoine,
J.-C. Pairon,
Marie Karanian,
Sanja Đačić,
Nicolas Girard,
Andrew Churg,
Franck Tirode,
Françoise Galateau-Sallé
Publication year - 2022
Publication title -
archives of pathology and laboratory medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.79
H-Index - 117
eISSN - 1543-2165
pISSN - 0003-9985
DOI - 10.5858/arpa.2021-0331-oa
Subject(s) - cdkn2a , fluorescence in situ hybridization , immunohistochemistry , in situ hybridization , staining , pathology , biology , cancer research , microbiology and biotechnology , medicine , cancer , gene expression , genetics , gene , chromosome
Homozygous deletion (HD) of CDKN2A is one of the most frequent genetic abnormalities in pleural mesotheliomas. HD of CDKN2A by fluorescence in situ hybridization (FISH) is a reliable marker of malignancy in mesothelial proliferations; however, evaluation of CDKN2A deletion requires FISH. The 9p21 locus includes both CDKN2A and MTAP (methylthioadenosine phosphorylase); the latter is frequently codeleted with CDKN2A.