Open AccessRepair of damaged intestinal mucosa in a mouse model of sepsis
Author(s) -
Ruiming Chang,
Wen Li,
Jian-xing Chang,
Yu-ru Fu,
Zhipeng Jiang,
Shuang Chen
Publication year - 2013
Publication title -
world journal of emergency medicine
Language(s) - English
Resource type - Journals
ISSN - 1920-8642
DOI - 10.5847/wjem.j.issn.1920-8642.2013.03.012
Subject(s) - sepsis , medicine , intestinal mucosa , immunohistochemistry , multiple organ dysfunction syndrome , western blot , pathology , apoptosis , h&e stain , goblet cell , ligation , intestinal epithelium , immunology , gastroenterology , epithelium , biology , biochemistry , gene
The intestine is not only the main target attacked by sepsis but also the vital organ which mediated sepsis. The recovery of the damaged intestinal barrier structure and function is related to the occurrence and outcome of multiple organ dysfunction syndrome (MODS). How to protect and reduce the damage of the intestinal mucosa and how to promote the reconstruction of the intestinal mucosa have been the important topics in sepsis for many years. This study aimed to investigate the influential factors of intestinal mucosal reconstruction after intestinal epithelial injury in vivo in a mouse model of sepsis.