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Gerek toplum kaynakli gerekse hastane kaynakli uriner sistem infeksiyonlarinda en sik izole edilen etken Escherichia coli'dir. Bu calisma, bolgemizdeki Escherichia coli suslarinin cesitli antibiyotiklere direnc durumlarinin belirlenmesi ve ampirik tedavi seceneklerinde yol gosterici olmasi amaciyla yapilmistir. 129 toplum kokenli, 120 hastane kokenli susun, "National Committee for Clinical Laboratory Standards (NCCLS)" onerilerine uygun olarak Kirby-Bauer disk difuzyon yontemi ile antibiyotik duyarliliklari belirlenmistir. Hastane kokenli suslar tum antibiyotiklere daha direncli olup, her iki epidemiyolojik grupta da en direncli gorulen antibiyotigin ampisilin (%48.8 - %83.3), en az direncli gorulen antibiyotigin ise amikasin (%0.8 - %4.2) oldugu saptanmistir. Trimetoprim-sulfametoksazol (TMP-SMX) direnci, toplum ve hastane kaynakli Escherichia coli suslarinda sirasiyla, %39.5 ve %65.0, sip-rofloksasin direnci ise, %16.3 ve %38.3 olarak bulunmustur. Bolgemizdeki toplum kokenli uriner sistem infeksiyonlarinin da ampirik tedavisinde TMP-SMX'in tercih edilmemesi gerektigi gorulmustur    The Antibiotic Resistance of Escherichia coli Strains Isolated From Urine Specimens From Hospital and community Originated Urinary Tract Infections  The most frequently isolated agent both from community and hospital originated urinary system infections is Escherichia coli. The aim of this study was to determine the resistance states of Escherichia coli species to various antibiotics and to direct empirical treatment choices in our city. The antibiotic sensitivities were determined in 129 community originated and in 120 hospital-originated species by Kirby-Bauer disc diffusion method, which was relevant with National Committee for Clinical Laboratory Standards (NCCLS). The hospital-originated species were found to be more resistant to all antibiotics. The antibiotic with the most frequent resistance was ampicillin (48.8%-83.3%) and with the least frequent resistance was amikacin (0.8%-4.2%) in both epidemiologic groups. Trimethoprim-sulfamethoxazole (TMP-SMX) resistance was found in 39.5% and 65.0% of species originated from community and hospital, respectively. Ciprofloxacin resistance were found 16.3% and 38.3% of species originated from community and hospital, respectively. In conclusion, we considered that the use of TMP-SMX shouldn't be recommended in empirical treatment of urinary tract infections originated from community.

İdrar Örneklerinden izole Edilen Toplum ve Hastane Kaynaklı Escherichia Coli Suşlarında Antibiyotik Direnci