Role of the ACE ID and PPARG P12A Polymorphisms in Genetic Susceptibility of Diabetic Nephropathy in a South Indian Population | Zendy

L.V.K.S. Bhaskar | Zendy; Sultana Mahin | Zendy; Raju Thankabai Ginila | Zendy; Soundararajan Periyasamy | Zendy

Open Access

Role of the ACE ID and PPARG P12A Polymorphisms in Genetic Susceptibility of Diabetic Nephropathy in a South Indian Population

Author(s) -

L.V.K.S. Bhaskar,

Sultana Mahin,

Raju Thankabai Ginila,

Soundararajan Periyasamy

Publication year - 2013

Publication title -

nephro-urology monthly

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 18

eISSN - 2251-7014

pISSN - 2251-7006

DOI - 10.5812/numonthly.9573

Subject(s) - peroxisome proliferator activated receptor gamma , diabetic nephropathy , medicine , diabetes mellitus , endocrinology , nephropathy , genotype , population , albuminuria , odds ratio , angiotensin converting enzyme , biology , blood pressure , peroxisome proliferator activated receptor , genetics , receptor , gene , environmental health

Diabetic nephropathy (DN) is one of the life-threatening disorders characterized by persistent albuminuria, raised arterial blood pressure, a lowered glomerular filtration rate, and high risk of cardiovascular morbidity and mortality. The vascular genes ACE (Angiotensin-converting enzyme), and PPARG (peroxisome proliferator activated receptor gamma) are involved in alterations in vascular endothelium, and are suggested to play a role in the susceptibility of diabetic nephropathy.

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