Open AccessSplenic Marginal Zone Lymphoma andConcurrentMembranoproliferative Glomerulonephritis With IgMKappa Deposits in a HCV-Seropositive Patient
Author(s) -
Eleni Chelioti,
Evdokia Efthimiou,
Maria Sotiraki,
Alexia Papalexandrou,
Maria Tsilivigkou
Publication year - 2014
Publication title -
nephro-urology monthly
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.15
H-Index - 18
eISSN - 2251-7014
pISSN - 2251-7006
DOI - 10.5812/numonthly.18391
Subject(s) - membranoproliferative glomerulonephritis , hepatosplenomegaly , splenic marginal zone lymphoma , medicine , lymphoplasmacytic lymphoma , pathology , lymphoproliferative disorders , cryoglobulinemia , renal biopsy , biopsy , lymphoma , hepatitis c , glomerulonephritis , bone marrow , hepatitis c virus , immunology , disease , spleen , kidney , virus , waldenstrom macroglobulinemia , splenectomy
We report a case of membranoproliferative glomerulonephritis (MPGN) with IgMκ light chain deposits in a patient with chronic hepatitis C infection and simultaneous onset of monoclonal IgMκ gammopathy with concurrent small B-cell lymphoproliferative disease. The patient presented with hepatosplenomegaly and a uremic state that necessitated dialysis without any clinical signs of systemic disease apart from the chronic infection with hepatitis C virus. The diagnostic approach led to a renal biopsy that revealed MPGN with dominant IgMκ deposits and interstitium infiltration by the lymphoid cells. The bone marrow biopsy findings were consistent with splenic marginal zone lymphoma, a rare lymphoproliferative disorder with a rare association with MPGN. Our case indicates high diagnostic value of renal biopsy for rare lymphoplasmacytic neoplasms with renal dysfunction as their predominant clinical manifestation.