Human Cytomegalovirus in Oral Squamous Cell Carcinoma in Southeast of Iran | Zendy

Shirin Saravani | Zendy; Hamideh Kadeh | Zendy; Ebrahim MiriMoghaddam | Zendy; Ali Zekri | Zendy; Nima Sanadgol | Zendy; Aliye Gholami | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Human Cytomegalovirus in Oral Squamous Cell Carcinoma in Southeast of Iran

Author(s) -

Shirin Saravani,

Hamideh Kadeh,

Ebrahim MiriMoghaddam,

Ali Zekri,

Nima Sanadgol,

Aliye Gholami

Publication year - 2015

Publication title -

jundishapur journal of microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.281

H-Index - 29

eISSN - 2008-4161

pISSN - 2008-3645

DOI - 10.5812/jjm.21838

Subject(s) - medicine , human cytomegalovirus , basal cell , carcinogenesis , virus , cytomegalovirus , pathology , pathogenesis , polymerase chain reaction , cancer , virology , viral disease , biology , herpesviridae , gene , biochemistry

Carcinogenesis is a multi-step process and the role of infectious agents in this progression has not been fully identified. Since human cytomegalovirus (HCMV) is frequently presented in the gingival sulcus fluid, we hypothesized that this virus would be important in the pathogenesis of oral squamous cell carcinoma (OSCC).The aim of this study was to investigate the presence of active HCMV in different histopathological grades of OSCC in southeast of Iran.Forty eight individual specimens were evaluated in this study. Serial sections were obtained from paraffin-embedded tissue samples of OSCC biopsies. The frequency of HCMV was investigated using the real-time polymerase change reaction method after DNA extraction from biopsies.The mean age of the patients (66.7% female and 33.3% male) was 58.6 years. Only three cases (6.3%) of the grade I, OSCC biopsies, were positive for active HCMV with average load of 57.7 × 10(3).According to the low prevalence of HCMV in OSCC, it seems that this virus plays a minor role in this kind of cancer at least in southeast of Iran. More comprehensive studies are needed to investigate the oncomodulatory effect of this virus on OSCC.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research