Fluconazole Resistance Candida albicans in Females With Recurrent Vaginitis and Pir1 Overexpression | Zendy

Zahra Nasrollahi | Zendy; Mohammad Hossein Yadegari | Zendy; Shahla Roudbar Mohammadi | Zendy; Maryam Roudbari | Zendy; Maryam Hosseini Poor | Zendy; Fatemeh Nikoomanesh | Zendy; M. Rajabi Bazl | Zendy

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Fluconazole Resistance Candida albicans in Females With Recurrent Vaginitis and Pir1 Overexpression

Author(s) -

Zahra Nasrollahi,

Mohammad Hossein Yadegari,

Shahla Roudbar Mohammadi,

Maryam Roudbari,

Maryam Hosseini Poor,

Fatemeh Nikoomanesh,

M. Rajabi Bazl

Publication year - 2015

Publication title -

jundishapur journal of microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.281

H-Index - 29

eISSN - 2008-4161

pISSN - 2008-3645

DOI - 10.5812/jjm.21468

Subject(s) - fluconazole , candida albicans , corpus albicans , vaginitis , microbiology and biotechnology , azole , medicine , drug resistance , polymerase chain reaction , gene , biology , antifungal , genetics , gynecology

Some genes may be associated with Candida albicans resistance to azoles. Pir1 gene is described as responsible to induce resistance in C. albicans.The current study aimed to find the relationship between fluconazole resistance and Pir1 protein (Pir1p) overexpression in the females with recurrent C. albicans vaginitis requiring longer fluconazole therapy.A total of 52l vaginal samples were obtained from the females with C. albicans vaginitis. The azole susceptibility phenotype was determined according to the Clinical Laboratory for Standards Institute (CLSI) protocol for disk diffusion method and inhibition zone for fluconazole. Expression of pir1 gene and fluconazole -resistance were evaluated using polymerase chain reaction (PCR) in C. albicans.In the 52 isolates, 49 (94%) were resistant to fluconazole. Overexpression of Pir1 gene was detected in 47 (96%) fluconazole-resistant C. albicans isolates.The findings show fluconazole -resistance in C. albicans isolates with overexpression of Pir1p.

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