Open AccessAnti-inflammatory Properties of the Genus Symphytum L.: A Review
Author(s) -
Elaheh Mahmoudzadeh,
Hossein Nazemiyeh,
Sanaz Hamedeyazdan
Publication year - 2022
Language(s) - English
Resource type - Journals
ISSN - 1726-6882
DOI - 10.5812/ijpr.123949
Subject(s) - genus , traditional medicine , medicine , anti inflammatory , pharmacology , biology , botany
: The Symphytum genus has been mainly used in traditional medicine, containing its anti-inflammatory activity. Symphytum spp.’s active components, such as allantoin, polyphenols, flavonoids, and alkaloids, can act on several intentions in the signaling pathway, constrain pro-inflammatory enzymes, reducing the construction of inflammatory chemokine’s and cytokines, and decreasing oxidative stress, which afterward suppresses inflammation procedures. Preclinical and clinical trials have reported the prevailing anti-inflammatory effect of several Symphytum species. This review presents an overview of the anti-inflammatory activities of different products and bioactive constituents in this genus. The papers with the English language were gathered from 2000 to 2021. This review may provide a scientific base for establishing innovative and alternative techniques for isolating a single individual from this genus to attenuate inflammatory disorders. The Symphytum genus is waiting for researchers to develop safe and effective anti-inflammatory agents for additional investigation of other different mechanisms of action.