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Background:  Relapse prevention is a medical intervention designed for educating cognitive and behavioral skills to avoid continued drug abuse and relapse.    Objectives:  This study examined high risk situations for relapse for self-referred addicts are related in Bushehr province substance abuse treatment centers.    Patients and Methods:  The present study is descriptive cross-sectional. The sample size consisted of 609 self-referred addicts to Bushehr province substance abuse centers. IDTS Marlatt questionnaire was used. Analytical and descriptive statistics were used to analyze the data.    Results:  The findings showed that 73.1% of addicts have used substance during the past 12 months, and 72% have experienced a full relapse. Unpleasant emotions and physical discomfort was the most important reason for relapse and testing personal control and pleasure emotions the least important reason. Interpersonal factors have also a great role in this regard.    Conclusions:  Considering the high rates of relapse, more attention should be paid to reasons for relapse. It seems necessary that both clinical and psychological approaches would be undertaken simultaneously.

High Risk Situations Predicting Relapse in Self-referred Addicts to Bushehr Province Substance Abuse Treatment Centers