Construction of Plasmid Insulin Gene Vector Containing Metallothionein IIA (pcDNAMTChIns) and Carbohydrate Response Element (ChoRE), and Its Expression in NIH3T3 Cell Line | Zendy

Hossein Piri | Zendy; Bahram Kazemi | Zendy; Mohsen Rezaei | Zendy; Mojgan Bandehpour | Zendy; Iraj Khodadadi | Zendy; Taghi Hassanzadeh | Zendy; Jamshid Karimi | Zendy; Fatemeh Yarian | Zendy; Habibollah Peirovi | Zendy; Amir Tavakoli | Zendy; Mohammad Taghi Goodarzi | Zendy

Open Access

Construction of Plasmid Insulin Gene Vector Containing Metallothionein IIA (pcDNAMTChIns) and Carbohydrate Response Element (ChoRE), and Its Expression in NIH3T3 Cell Line

Author(s) -

Hossein Piri,

Bahram Kazemi,

Mohsen Rezaei,

Mojgan Bandehpour,

Iraj Khodadadi,

Taghi Hassanzadeh,

Jamshid Karimi,

Fatemeh Yarian,

Habibollah Peirovi,

Amir Tavakoli,

Mohammad Taghi Goodarzi

Publication year - 2012

Publication title -

international journal of endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.652

H-Index - 23

eISSN - 1726-9148

pISSN - 1726-913X

DOI - 10.5812/ijem.4540

Subject(s) - microbiology and biotechnology , plasmid , restriction enzyme , gene , transfection , biology , genetic enhancement , gene expression , complementary dna , cloning (programming) , genetics , computer science , programming language

Type 1 diabetes mellitus is one of the metabolic diseases that cause insulin-producing pancreatic ß cells be destroyed by immune system self-reactive T cells. Recent-ly, new treatment methods have been developed including use of the stem cells, ß islet cells transplantation and gene therapy by viral and non-viral gene constructs.

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