Augmented Renal Clearance in Iranian Critically Ill Patients: Retrospective Study at Masih Daneshvari Hospital

Background: Patients admitted to intensive care units have different physiological parameters in comparison with other settings. Changes in cardiovascular and renal functions are characteristics of these patients. An augmented renal clearance (ARC) has been investigated in some groups of critically ill patients, but there are no studies on the occurrence and determinants of ARC in Iran. Objectives: Our goal was to determine the incidence and associated factors of ARC in Iranian critically ill patients. Methods: This retrospective cohort study was conducted on patients admitted to the mixed medical-surgical ICU of Masih Daneshvari hospital, Tehran, Iran, as a referral center, during a 3-year period (October 2010 to October of 2012). ARC was defined as creatinine clearance (CLCr) ≥ 130 mL/min/1.73 m2. Two groups were analyzed: medical and surgical admission in ICU. Results: Augmented renal clearance was present in 184 of 467 Iranian patients (39.4%), and they were young (42.1 ± 14.6 versus 58 ± 1 years, P value < 0.01). Conclusions: In this cohort of Iranian critically ill patients, 39.4% had ARC on admission to the ICU. Augmented renal clearance mainly developed in young Iranian patients.