Open AccessTherapeutic uses of exosomes
Author(s) -
Zacharias E. Suntres,
Milton Smith,
Fatemeh MomenHeravi,
Jie Hu,
Xin Zhang,
Ying Wu,
Hongguang Zhu,
Jiping Wang,
Jian Zhou,
Winston Patrick Kuo
Publication year - 2013
Publication title -
exosomes and microvesicles
Language(s) - English
Resource type - Journals
ISSN - 1848-9214
DOI - 10.5772/56522
Subject(s) - microvesicles , immunology , antigen , cd63 , disease , cell , cell type , medicine , biology , cancer research , pathology , microrna , biochemistry , genetics , gene
Exosomes are membrane vesicles with a diameter of 40–100 nm that are secreted by many cell types into the extracellular milieu. Exosomes are found in cell culture supernatants and in different biological fluids and are known to be secreted by most cell types under normal and pathological conditions. Considerable research is focusing on the exploitation of exosomes in biological fluids for biomarkers in the diagnosis of disease. More recently, exosomes are being exploited for their therapeutic potential. Exosomes derived from dendritic cells, tumor cells, and malignant effusions demonstrate immunomodulatory functions and are able to present antigens to T-cells and stimulate antigen-specific T-cell responses. Exosomes have also been examined for their therapeutic potential in the treatment of infections such as toxoplasmosis, diphtheria, tuberculosis and atypical severe acute respiratory syndrome as well as autoimmune diseases. Attempts to find practical applications for exosomes continue to expand with the role of exosomes as a drug delivery system for the treatment of autoimmune/inflammatory diseases and cancers