Late - Onset Hypogonadism - New Point of View

Long-term testosterone deficiency related to age may adversely affect health, anatomy and physiology of man. The implementation of testosterone boost therapy only at the time, when for many years, as the result of testosterone deficiency, irreversible anatomical changes have occurred, is clearly too late. Age-related progressive decrease in testosterone serum concentration levels causes anatomical and functional abnormalities. It is the cause of lipid disorders; it excarberates type-2 diabetes, it is also the common cause of cardiovascular diseases. It contributes to other health problems such as atherosclerosis, hypertension, osteoporosis and obesity and it manifests itself by decreased libido and potency. There is also a strong relationship between age-related decrease in testosterone and Parkinson's disease and Alzheimer's disease. Benign prostatic hyperplasia (BPH) and carcinoma of the prostate are closely associated with testosterone deficiency and comedo-carcinoma — the most malignant form of prostate cancer — is directly proportional to the decrease in serum testosterone. A good therapy for increasing testosterone serum levels can reverse the problems associated with aging such as type-2 diabetes, sexual dysfunction, osteoporosis, hyper-lipidemia and ischemic heart disease. It can even reverse symptoms of Parkinson's disease. Using synthetic testosterone is often recommended in the treatment of testosterone deficiency. Unfortunately, synthetic testosterone can cause side effects such as infertility and a long-term use of testosterone may also lead to irreversible testicular atrophy. Therefore, patients receiving long-term testosterone therapy are all dependent on adequate doses of synthetic testosterone until the end of their lives. Meanwhile, intramuscular administration of hCG to stimulate the endogenous testosterone synthesis, has been known since the 1950s. The induction of endogenous testosterone production by hCG has been effective in all age groups while being safe at the same time. In this paper, the author presents problems caused by testosterone deficiency and outlines the possibility of the treatment, which increases the induction of testosterone endosynthesis by hCG. It has not yet been determined how to diagnose testosterone deficiency. The age-related serum testosterone concentration reference range has not been established yet either. The paper presents the first attempt to establish international standards for testosterone serum concentration levels in different age groups.