Oral Abstract Presentations at the 8th Canadian Conference on Dementia (CCD), Ottawa, October 2015

Background/Objectives: Psychosis (delusions or hallucinations) is a common clinical feature in patients with Alzheimer’s disease (AD), and is estimated to affect up to half of this patient population. Psychosis is associated with increased cognitive and functional decline as well as greater caregiver burden. However, lack of understanding of the pathobiological mechanisms behind psychosis limits our ability to manage and treat these symptoms. The current literature is mixed, with some studies showing a correlation between psychosis and Alzheimer pathology, while others find no such association. Using data from the large National Alzheimer’s Coordinating Center (NACC) database, we aimed to determine the demographic, clinical, and neuropathological features associated with psychotic symptoms, separated into delusions and/or hallucinations, in patients who were clinically or neuropathologically diagnosed with AD.