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and remits dramatically after the placenta has been delivered. Despite extensive research, the pathophysiology of this condition remains unclear. Accumulating evidence, however, indicates that failure of the cytotrophoblast invasion of maternal uterine spiral arteries plays a central role. 4) Consequently, reduction of utero placental blood perfusion by shallow implantation results in local placental hypoxia. Chronic hypoxia Maternal Plasma Hepatocyte Growth Factor Concentrations in Women Who Subsequently Developed Preeclampsia