Vascular Dysfunction in Short-Term Hypercholesterolemia despite the Absence of Atherosclerotic Lesions.
Author(s) -
Alireza Garjani,
Y Azarmiy,
A Zakheri,
Allaf Akbari N,
Sina Andalib,
Nasrin MalekiDizaji
Publication year - 2011
Publication title -
pubmed
Language(s) - English
Resource type - Journals
ISSN - 2008-5117
DOI - 10.5681/jcvtr.2011.016
Subject(s) - medicine , lovastatin , hyperlipidemia , lesion , thoracic aorta , cholesterol , aorta , endothelium , high cholesterol , endocrinology , blood lipids , vasodilation , arteriosclerosis , diabetes mellitus , surgery
The atherosclerotic effect of hypercholesterolemia on the vascular function is well-known. However, limited studies were done on the effect of hypercholesterolemia without atherosclerotic lesion on the vascular compliance. The aim of this study was to investigate the effects of hyperlipidemia induced by cholesterol rich diet on vessel function in isolated rat aorta in the absence of atherosclerotic lesion.
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