Chiral separation of indapamide enantiomers by capillary electrophoresis. | Zendy

Amelia Tero-Vescan | Zendy; Gabriel Hancu | Zendy; Mihaela Oroian | Zendy; Anca Gabriela Cârje | Zendy

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Chiral separation of indapamide enantiomers by capillary electrophoresis.

Author(s) -

Amelia Tero-Vescan,

Gabriel Hancu,

Mihaela Oroian,

Anca Gabriela Cârje

Publication year - 2014

Publication title -

pubmed

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.773

H-Index - 35

ISSN - 2228-5881

DOI - 10.5681/apb.2014.039

Subject(s) - indapamide , capillary electrophoresis , enantiomer , chromatography , chemistry , electrolyte , sodium , electrophoresis , diuretic , pharmacology , stereochemistry , organic chemistry , medicine , electrode

Indapamide is probably the most frequently prescribed diuretic drug, generally being used for the treatment of hypertension. It contains a chiral center in its molecule; is marketed as a racemic mixture; but there are rather few studies regarding the pharmacokinetic and the pharmacological effect differences of the two enantiomers. Our aim was the development of a simple, rapid and precise analytical procedure for the chiral separation of indapamide enantiomers.

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