Effect on Intermittent Hypoxia on Plasma Exosomal Micro RNA Signature and Endothelial Function in Healthy Adults
Author(s) -
Abdelnaby Khalyfa,
Chunling Zhang,
Ahamed Khalyfa,
Glen E. Foster,
Andrew E. Beaudin,
Jorge Andrade,
Patrick J. Hanly,
Marc J. Poulin,
David Gozal
Publication year - 2016
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.5665/sleep.6302
Subject(s) - hypoxia (environmental) , medicine , cardiology , endocrinology , chemistry , oxygen , organic chemistry
Intermittent hypoxia (IH) is associated with increased risk of cardiovascular disease. Exosomes are secreted by most cell types and released in biological fluids, including plasma, and play a role in modifying the functional phenotype of target cells. Using an experimental human model of IH, we investigated potential exosome-derived biomarkers of IH-induced vascular dysfunction.
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