Fragmentation of Rapid Eye Movement and Nonrapid Eye Movement Sleep without Total Sleep Loss Impairs Hippocampus-Dependent Fear Memory Consolidation | Zendy

Michael L. Lee | Zendy; Ângela M. Katsuyama | Zendy; Leanne S. Duge | Zendy; Chaitra Sriram | Zendy; Mykhaylo Krushelnytskyy | Zendy; Jeansok J. Kim | Zendy; Horacio O. de la Iglesia | Zendy

Open Access

Fragmentation of Rapid Eye Movement and Nonrapid Eye Movement Sleep without Total Sleep Loss Impairs Hippocampus-Dependent Fear Memory Consolidation

Author(s) -

Michael L. Lee,

Ângela M. Katsuyama,

Leanne S. Duge,

Chaitra Sriram,

Mykhaylo Krushelnytskyy,

Jeansok J. Kim,

Horacio O. de la Iglesia

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.6236

Subject(s) - non rapid eye movement sleep , psychology , memory consolidation , sleep deprivation , neuroscience , hippocampus , rapid eye movement sleep , eye movement , neuroscience of sleep , sleep (system call) , sleep spindle , circadian rhythm , computer science , operating system

Sleep is important for consolidation of hippocampus-dependent memories. It is hypothesized that the temporal sequence of nonrapid eye movement (NREM) sleep and rapid eye movement (REM) sleep is critical for the weakening of nonadaptive memories and the subsequent transfer of memories temporarily stored in the hippocampus to more permanent memories in the neocortex. A great body of evidence supporting this hypothesis relies on behavioral, pharmacological, neural, and/or genetic manipulations that induce sleep deprivation or stage-specific sleep deprivation.

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