Normoxic Recovery Mimicking Treatment of Sleep Apnea Does Not Reverse Intermittent Hypoxia-Induced Bacterial Dysbiosis and Low-Grade Endotoxemia in Mice | Zendy

Isabel MorenoIndias | Zendy; Marta Torres | Zendy; Lidia SánchezAlcoholado | Zendy; Fernando Cardona | Zendy; Isaac Almendros | Zendy; David Gozal | Zendy; Josep M. Montserrat | Zendy; María Isabel QueipoOrtuño | Zendy; Ramón Farré | Zendy

Open Access

Normoxic Recovery Mimicking Treatment of Sleep Apnea Does Not Reverse Intermittent Hypoxia-Induced Bacterial Dysbiosis and Low-Grade Endotoxemia in Mice

Author(s) -

Isabel MorenoIndias,

Marta Torres,

Lidia SánchezAlcoholado,

Fernando Cardona,

Isaac Almendros,

David Gozal,

Josep M. Montserrat,

María Isabel QueipoOrtuño,

Ramón Farré

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.6176

Subject(s) - intermittent hypoxia , firmicutes , gut flora , bacteroidetes , pyrosequencing , dysbiosis , biology , akkermansia , hypoxia (environmental) , microbiome , obstructive sleep apnea , medicine , endocrinology , ruminococcus , microbiology and biotechnology , immunology , lactobacillus , chemistry , 16s ribosomal rna , food science , bacteria , biochemistry , bioinformatics , organic chemistry , oxygen , gene , genetics , fermentation

Intermittent hypoxia (IH) mimicking obstructive sleep apnea (OSA) significantly modifies gut microbiota in mice. However, whether these IH-induced gut microbiome changes are reversible after restoring normal oxygenation (the equivalent of effective OSA therapy) is unknown. The aim of this study was to investigate gut microbiota composition and circulating endotoxemia after a post-IH normoxic period in a mouse model of OSA.

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