Sleep-Wake Differences in Relative Regional Cerebral Metabolic Rate for Glucose among Patients with Insomnia Compared with Good Sleepers | Zendy

Daniel B. Kay | Zendy; Helmet T. Karim | Zendy; Adriane M. Soehner | Zendy; Brant P. Hasler | Zendy; Kristine A. Wilckens | Zendy; Jeffrey A. James | Zendy; Howard Aizenstein | Zendy; Julie C. Price | Zendy; Bedda L. Rosario | Zendy; David J. Kupfer | Zendy; Anne Germain | Zendy; Martica H. Hall | Zendy; Peter L. Franzen | Zendy; Eric A. Nofzinger | Zendy; Daniel J. Buysse | Zendy

Open Access

Sleep-Wake Differences in Relative Regional Cerebral Metabolic Rate for Glucose among Patients with Insomnia Compared with Good Sleepers

Author(s) -

Daniel B. Kay,

Helmet T. Karim,

Adriane M. Soehner,

Brant P. Hasler,

Kristine A. Wilckens,

Jeffrey A. James,

Howard Aizenstein,

Julie C. Price,

Bedda L. Rosario,

David J. Kupfer,

Anne Germain,

Martica H. Hall,

Peter L. Franzen,

Eric A. Nofzinger,

Daniel J. Buysse

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.6154

Subject(s) - non rapid eye movement sleep , precuneus , psychology , wakefulness , posterior cingulate , sleep onset , polysomnography , medicine , audiology , neuroscience , insomnia , cortex (anatomy) , eye movement , psychiatry , cognition , electroencephalography

The neurobiological mechanisms of insomnia may involve altered patterns of activation across sleep-wake states in brain regions associated with cognition, self-referential processes, affect, and sleep-wake promotion. The objective of this study was to compare relative regional cerebral metabolic rate for glucose (rCMR glc ) in these brain regions across wake and nonrapid eye movement (NREM) sleep states in patients with primary insomnia (PI) and good sleeper controls (GS).

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