Impact of Astroglial Connexins on Modafinil Pharmacological Properties | Zendy

Adeline Duchêne | Zendy; Magali Perier | Zendy; Yan Zhao | Zendy; Xinhe Liu | Zendy; Julien Thomasson | Zendy; Frédéric Chauveau | Zendy; Christophe Piérard | Zendy; D. Lagarde | Zendy; Christèle Picoli | Zendy; Tiffany Jeanson | Zendy; Franck Mouthon | Zendy; Yves Dauvilliers | Zendy; Christian Giaume | Zendy; JianSheng Lin | Zendy; Mathieu Charvériat | Zendy

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Impact of Astroglial Connexins on Modafinil Pharmacological Properties

Author(s) -

Adeline Duchêne,

Magali Perier,

Yan Zhao,

Xinhe Liu,

Julien Thomasson,

Frédéric Chauveau,

Christophe Piérard,

D. Lagarde,

Christèle Picoli,

Tiffany Jeanson,

Franck Mouthon,

Yves Dauvilliers,

Christian Giaume,

JianSheng Lin,

Mathieu Charvériat

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5854

Subject(s) - modafinil , pharmacology , narcolepsy , connexin , neuroscience , flecainide , medicine , chemistry , psychology , gap junction , biochemistry , intracellular , atrial fibrillation

Modafinil is a non-amphetaminic wake-promoting compound used as therapy against sleepiness and narcolepsy. Its mode of action is complex, but modafinil has been recently proposed to act as a cellular-coupling enhancer in glial cells, through modulation of gap junctions constituted by connexins. The present study investigated in mice the impact of connexins on the effects of modafinil using connexin inhibitors.

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