Localizing Effects of Leptin on Upper Airway and Respiratory Control during Sleep | Zendy

Qiaoling Yao | Zendy; Huy Pho | Zendy; Jason P. Kirkness | Zendy; Ellen E. Ladenheim | Zendy; Sheng Bi | Zendy; Timothy H. Moran | Zendy; David D. Fuller | Zendy; Alan R. Schwartz | Zendy; Vsevolod Y. Polotsky | Zendy

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Localizing Effects of Leptin on Upper Airway and Respiratory Control during Sleep

Author(s) -

Qiaoling Yao,

Huy Pho,

Jason P. Kirkness,

Ellen E. Ladenheim,

Sheng Bi,

Timothy H. Moran,

David D. Fuller,

Alan R. Schwartz,

Vsevolod Y. Polotsky

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5762

Subject(s) - leptin , airway , respiratory system , sleep (system call) , medicine , psychology , anesthesia , obesity , computer science , operating system

Obesity hypoventilation and obstructive sleep apnea are common complications of obesity linked to defects in respiratory pump and upper airway neural control. Leptin-deficient ob/ob mice have impaired ventilatory control and inspiratory flow limitation during sleep, which are both reversed with leptin. We aimed to localize central nervous system (CNS) site(s) of leptin action on respiratory and upper airway neuroventilatory control.

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