Open AccessAberrant Insular Functional Network Integrity in Patients with Obstructive Sleep Apnea
Author(s) -
Bumhee Park,
Jose A. Palomares,
Mary A. Woo,
Daniel W. Kang,
Paul M. Macey,
Frisca L. YanGo,
Ronald M. Harper,
Rajesh Kumar
Publication year - 2016
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.5665/sleep.5738
Subject(s) - insular cortex , insula , functional magnetic resonance imaging , brainstem , neuroscience , obstructive sleep apnea , psychology , thalamus , posterior cingulate , resting state fmri , functional imaging , cingulate cortex , medicine , cardiology , central nervous system
Obstructive sleep apnea (OSA) is accompanied by tissue injury to the insular cortices, areas that regulate autonomic pain, dyspnea, and mood, all of which are affected in the syndrome. Presumably, the dysregulation of insular-related functions are mediated by aberrant functional connections with other brain regions; however, the integrity of the functional connectivity (FC) to other sites is undescribed. Our aim was to examine resting-state FC of the insular cortices to other brain areas in OSA, relative to control subjects.
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