Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia
Author(s) -
Shantel L. Duffy,
Jim Lagopoulos,
Zoë Terpening,
Simon J.G. Lewis,
Ronald R. Grunstein,
Loren Mowszowski,
Nathan Cross,
Daniel F. Hermens,
Ian B. Hickie,
Sharon L. Naismith
Publication year - 2016
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.5665/sleep.5650
Subject(s) - dementia , association (psychology) , sleep apnea , medicine , sleep (system call) , anterior cingulate cortex , apnea , cardiology , audiology , psychiatry , psychology , cognition , disease , computer science , psychotherapist , operating system
Sleep disordered breathing (SDB) is common in older adults and is strongly associated with cognitive decline, with increasing evidence suggesting that it may represent a risk factor for dementia. Given that SDB is characterized by intermittent episodes of hypoxemia during sleep, it is possible that cognitive impairment may relate to cerebral oxidative stress. This study aimed to examine the relationship between nocturnal markers of hypoxemia and proton magnetic resonance spectroscopy ((1)H-MRS) markers of oxidative stress within the anterior cingulate cortex (ACC) of the brain.
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