Loss of Sleep Affects the Ultrastructure of Pyramidal Neurons in the Adolescent Mouse Frontal Cortex | Zendy

Luisa de Vivo | Zendy; Aaron B. Nelson | Zendy; Michele Bellesi | Zendy; Juliaoguti | Zendy; Giulio Toi | Zendy; Chiara Cirelli | Zendy

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Loss of Sleep Affects the Ultrastructure of Pyramidal Neurons in the Adolescent Mouse Frontal Cortex

Author(s) -

Luisa de Vivo,

Aaron B. Nelson,

Michele Bellesi,

Juliaoguti,

Giulio Toi,

Chiara Cirelli

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5644

Subject(s) - sleep restriction , ultrastructure , sleep deprivation , sleep (system call) , psychology , neuroscience , frontal lobe , biology , endocrinology , audiology , medicine , anatomy , cognition , computer science , operating system

The adolescent brain may be uniquely affected by acute sleep deprivation (ASD) and chronic sleep restriction (CSR), but direct evidence is lacking. We used electron microscopy to examine how ASD and CSR affect pyramidal neurons in the frontal cortex of adolescent mice, focusing on mitochondria, endosomes, and lysosomes that together perform most basic cellular functions, from nutrient intake to prevention of cellular stress.

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