Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol | Zendy

Erin C. Hanlon | Zendy; Esra Tasali | Zendy; Rachel Leproult | Zendy; Kara L. Stuhr | Zendy; Elizabeth M. Doncheck | Zendy; Harriet de Wit | Zendy; Cecilia J. Hillard | Zendy; Eve Van Cauter | Zendy

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Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol

Author(s) -

Erin C. Hanlon,

Esra Tasali,

Rachel Leproult,

Kara L. Stuhr,

Elizabeth M. Doncheck,

Harriet de Wit,

Cecilia J. Hillard,

Eve Van Cauter

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5546

Subject(s) - endocannabinoid system , appetite , endocrinology , medicine , sleep restriction , sleep (system call) , circadian rhythm , 2 arachidonoylglycerol , wakefulness , obesity , crossover study , sleep deprivation , cannabinoid receptor , psychiatry , electroencephalography , receptor , computer science , agonist , operating system , placebo , alternative medicine , pathology

Increasing evidence from laboratory and epidemiologic studies indicates that insufficient sleep may be a risk factor for obesity. Sleep curtailment results in stimulation of hunger and food intake that exceeds the energy cost of extended wakefulness, suggesting the involvement of reward mechanisms. The current study tested the hypothesis that sleep restriction is associated with activation of the endocannabinoid (eCB) system, a key component of hedonic pathways involved in modulating appetite and food intake.

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