Smoking, Alcohol, Drug Use, Abuse and Dependence in Narcolepsy and Idiopathic Hypersomnia: A Case-Control Study | Zendy

Lucie Barateau | Zendy; Isabelle Jaussent | Zendy; Régis Lopez | Zendy; Benjamin Boutrel | Zendy; Smaranda LeuSemenescu | Zendy; Isabelle Arnulf | Zendy; Yves Dauvilliers | Zendy

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Smoking, Alcohol, Drug Use, Abuse and Dependence in Narcolepsy and Idiopathic Hypersomnia: A Case-Control Study

Author(s) -

Lucie Barateau,

Isabelle Jaussent,

Régis Lopez,

Benjamin Boutrel,

Smaranda LeuSemenescu,

Isabelle Arnulf,

Yves Dauvilliers

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5530

Subject(s) - narcolepsy , cannabis , medicine , psychiatry , alcohol dependence , confounding , substance abuse , substance dependence , addiction , craving , population , neurology , alcohol , biochemistry , chemistry , environmental health

Basic experiments support the impact of hypocretin on hyperarousal and motivated state required for increasing drug craving. Our aim was to assess the frequencies of smoking, alcohol and drug use, abuse and dependence in narcolepsy type 1 (NT1, hypocretin-deficient), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH) (non-hypocretin-deficient conditions), in comparison to controls. We hypothesized that NT1 patients would be less vulnerable to drug abuse and addiction compared to other hypersomniac patients and controls from general population.

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