Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease | Zendy

Simon P. Fisher | Zendy; Michael D. Schwartz | Zendy; Sarah Wurts-Black | Zendy; Alexia M. Thomas | Zendy; Tsui-Ming Chen | Zendy; Michael A. Miller | Zendy; Jeremiah B. Palmerston | Zendy; Thomas S. Kilduff | Zendy; Stephen R. Morairty | Zendy

Open Access

Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease

Author(s) -

Simon P. Fisher,

Michael D. Schwartz,

Sarah Wurts-Black,

Alexia M. Thomas,

Tsui-Ming Chen,

Michael A. Miller,

Jeremiah B. Palmerston,

Thomas S. Kilduff,

Stephen R. Morairty

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5448

Subject(s) - huntington's disease , electroencephalography , rapid eye movement sleep , neurodegeneration , sleep deprivation , disease , psychology , medicine , neuroscience , audiology , circadian rhythm

Patients with Huntington's disease (HD) show a high prevalence of sleep disorders that typically occur prior to the onset of motoric symptoms and neurodegeneration. Our understanding of the pathophysiological alterations in premanifest HD is limited, hindering the ability to measure disease modification in response to treatment. We used a full-length knock-in HD model to determine early changes in the electroencephalogram (EEG) and sleep that may predict the onset and progression of the disease.

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