Orexin Receptor Antagonism Improves Sleep and Reduces Seizures inKcna1-null Mice | Zendy

Harrison M. Roundtree | Zendy; Timothy A. Simeone | Zendy; Chaz Johnson | Zendy; Stephanie A. Matthews | Zendy; Kaeli Samson | Zendy; Kristina A. Simeone | Zendy

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Orexin Receptor Antagonism Improves Sleep and Reduces Seizures inKcna1-null Mice

Author(s) -

Harrison M. Roundtree,

Timothy A. Simeone,

Chaz Johnson,

Stephanie A. Matthews,

Kaeli Samson,

Kristina A. Simeone

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5444

Subject(s) - non rapid eye movement sleep , orexin , medicine , endocrinology , epilepsy , orexin receptor , psychology , neuroscience , electroencephalography , neuropeptide , receptor

Comorbid sleep disorders occur in approximately one-third of people with epilepsy. Seizures and sleep disorders have an interdependent relationship where the occurrence of one can exacerbate the other. Orexin, a wake-promoting neuropeptide, is associated with sleep disorder symptoms. Here, we tested the hypothesis that orexin dysregulation plays a role in the comorbid sleep disorder symptoms in the Kcna1-null mouse model of temporal lobe epilepsy.

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