TheDrosophilaCircadian Clock Gates Sleep through Time-of-Day Dependent Modulation of Sleep-Promoting Neurons | Zendy

Daniel J. Cavanaugh | Zendy; Abigail Vigderman | Zendy; Terry Dean | Zendy; David S. Garbe | Zendy; Amita Sehgal | Zendy

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TheDrosophilaCircadian Clock Gates Sleep through Time-of-Day Dependent Modulation of Sleep-Promoting Neurons

Author(s) -

Daniel J. Cavanaugh,

Abigail Vigderman,

Terry Dean,

David S. Garbe,

Amita Sehgal

Publication year - 2016

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5442

Subject(s) - circadian rhythm , circadian clock , sleep (system call) , biology , neuroscience , sleep deprivation , free running sleep , population , clock , light effects on circadian rhythm , endocrinology , medicine , environmental health , computer science , operating system

Sleep is under the control of homeostatic and circadian processes, which interact to determine sleep timing and duration, but the mechanisms through which the circadian system modulates sleep are largely unknown. We therefore used adult-specific, temporally controlled neuronal activation and inhibition to identify an interaction between the circadian clock and a novel population of sleep-promoting neurons in Drosophila.

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