Insomnia Caused by Serotonin Depletion is Due to Hypothermia | Zendy

N.M.F. Murray | Zendy; Gordon F. Buchanan | Zendy; George B. Richerson | Zendy

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Insomnia Caused by Serotonin Depletion is Due to Hypothermia

Author(s) -

N.M.F. Murray,

Gordon F. Buchanan,

George B. Richerson

Publication year - 2015

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5256

Subject(s) - serotonin , insomnia , hypothermia , serotonin syndrome , medicine , anesthesia , psychology , psychiatry , serotonergic , receptor

Serotonin (5-hydroxytryptamine, 5-HT) neurons are now thought to promote wakefulness. Early experiments using the tryptophan hydroxylase inhibitor para-chlorophenylalanine (PCPA) had led to the opposite conclusion, that 5-HT causes sleep, but those studies were subsequently contradicted by electrophysiological and behavioral data. Here we tested the hypothesis that the difference in conclusions was due to failure of early PCPA experiments to control for the recently recognized role of 5-HT in thermoregulation.

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