Identification of Sleep-Modulated Pathways Involved in Neuroprotection from Stroke | Zendy

Marta Pace | Zendy; Francesca Baracchi | Zendy; Bo Gao | Zendy; Claudio L. Bassetti | Zendy

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Identification of Sleep-Modulated Pathways Involved in Neuroprotection from Stroke

Author(s) -

Marta Pace,

Francesca Baracchi,

Bo Gao,

Claudio L. Bassetti

Publication year - 2015

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5148

Subject(s) - neuroprotection , sleep deprivation , downregulation and upregulation , ischemia , medicine , stroke (engine) , brain ischemia , ischemic preconditioning , gene expression , neuroscience , pharmacology , biology , gene , circadian rhythm , biochemistry , mechanical engineering , engineering

Sleep deprivation (SDp) performed before stroke induces an ischemic tolerance state as observed in other forms of preconditioning. As the mechanisms underlying this effect are not well understood, we used DNA oligonucleotide microarray analysis to identify the genes and the gene-pathways underlying SDp preconditioning effects.

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