Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity | Zendy

Gadintshware Gaoatswe | Zendy; Brian D. Kent | Zendy; Michelle Corrigan | Zendy; Geraldine Nolan | Zendy; Andrew E. Hogan | Zendy; Walter T. McNicholas | Zendy; Donal O’Shea | Zendy

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Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity

Author(s) -

Gadintshware Gaoatswe,

Brian D. Kent,

Michelle Corrigan,

Geraldine Nolan,

Andrew E. Hogan,

Walter T. McNicholas,

Donal O’Shea

Publication year - 2015

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5062

Subject(s) - obstructive sleep apnea , medicine , intermittent hypoxia , hypoxia (environmental) , immunology , apoptosis , endocrinology , biology , chemistry , oxygen , biochemistry , organic chemistry

Emerging evidence links obstructive sleep apnea (OSA) with increased cancer incidence and mortality. Invariant natural killer T (iNKT) cells play an important role in cancer immunity. We hypothesized that patients with OSA have low number of circulating invariant natural killer T (iNKT) cells, which may also be functionally impaired. This study aims to evaluate the frequency of circulating iNKT cells in OSA.

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