Chronic Intermittent Hypoxia Induces Chronic Low-Grade Neuroinflammation in the Dorsal Hippocampus of Mice | Zendy

Emilie Sapin | Zendy; Christelle Peyron | Zendy; Fréderic Roche | Zendy; Nadine Gay | Zendy; Carole Carcenac | Zendy; Marc Savasta | Zendy; Patrick Lévy | Zendy; Maurice Demattéis | Zendy

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Chronic Intermittent Hypoxia Induces Chronic Low-Grade Neuroinflammation in the Dorsal Hippocampus of Mice

Author(s) -

Emilie Sapin,

Christelle Peyron,

Fréderic Roche,

Nadine Gay,

Carole Carcenac,

Marc Savasta,

Patrick Lévy,

Maurice Demattéis

Publication year - 2015

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5042

Subject(s) - intermittent hypoxia , neuroinflammation , proinflammatory cytokine , medicine , hypoxia (environmental) , endocrinology , microglia , hippocampus , obstructive sleep apnea , inflammation , immunology , chemistry , organic chemistry , oxygen

Obstructive sleep apnea (OSA) induces cognitive impairment that involves intermittent hypoxia (IH). Because OSA is recognized as a low-grade systemic inflammatory disease and only some patients develop cognitive deficits, we investigated whether IH-related brain consequences shared similar pathophysiology and required additional factors such as systemic inflammation to develop.

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