The Role of the Serotonergic System in REM Sleep Behavior Disorder | Zendy

Dario Arnaldi | Zendy; Francesco Famà | Zendy; Fabrizio De Carli | Zendy; Silvia Morbelli | Zendy; Michela Ferrara | Zendy; Agnese Picco | Zendy; Jennifer Accardo | Zendy; A. Primavera | Zendy; Gianmario Sambuceti | Zendy; Flavio Nobili | Zendy

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The Role of the Serotonergic System in REM Sleep Behavior Disorder

Author(s) -

Dario Arnaldi,

Francesco Famà,

Fabrizio De Carli,

Silvia Morbelli,

Michela Ferrara,

Agnese Picco,

Jennifer Accardo,

A. Primavera,

Gianmario Sambuceti,

Flavio Nobili

Publication year - 2015

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.5000

Subject(s) - serotonergic , rem sleep behavior disorder , medicine , psychology , serotonin , thalamus , brainstem , basal ganglia , serotonin transporter , dopamine transporter , polysomnography , dopaminergic , midbrain , neuroscience , endocrinology , dopamine , central nervous system , receptor , apnea

REM sleep behavior disorder (RBD) can be induced by antidepressants, especially serotonin reuptake inhibitors (SSRI), thus a role of the serotonergic system in the pathogenesis of RBD has been proposed. However, the serotonergic system integrity in idiopathic RBD (iRBD) is still unknown. We aimed to study brain stem serotonergic system integrity, by means of (123)I-FP-CIT-SPECT, in a group of iRBD patients as compared to normal subjects.

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