Cacna1c(Cav1.2) Modulates Electroencephalographic Rhythm and Rapid Eye Movement Sleep Recovery | Zendy

Deependra Kumar | Zendy; Nina Dedic | Zendy; Cornelia Flachskamm | Zendy; Stephanie Voulé | Zendy; Jan M. Deussing | Zendy; Mayumi Kimura | Zendy

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Cacna1c(Cav1.2) Modulates Electroencephalographic Rhythm and Rapid Eye Movement Sleep Recovery

Author(s) -

Deependra Kumar,

Nina Dedic,

Cornelia Flachskamm,

Stephanie Voulé,

Jan M. Deussing,

Mayumi Kimura

Publication year - 2015

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.4972

Subject(s) - polysomnography , sleep (system call) , sleep deprivation , slow wave sleep , non rapid eye movement sleep , calcium channel , electroencephalography , rapid eye movement sleep , voltage dependent calcium channel , endocrinology , sleep spindle , circadian rhythm , medicine , sleep onset , psychology , neuroscience , insomnia , calcium , psychiatry , computer science , operating system

The CACNA1C gene encodes the alpha 1C (α1C) subunit of the Cav1.2 voltage-dependent L-type calcium channel (LTCC). Some of the other voltage-dependent calcium channels, e.g., P-/Q-type, Cav2.1; N-type, Cav2.2; E-/R-type, Cav2.3; and T-type, Cav3.3 have been implicated in sleep modulation. However, the contribution of LTCCs to sleep remains largely unknown. Based on recent genome-wide association studies, CACNA1C emerged as one of potential candidate genes associated with both sleep and psychiatric disorders. Indeed, most patients with mental illnesses have sleep problems and vice versa.

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