Increased Carbonic Anhydrase Activity is Associated with Sleep Apnea Severity and Related Hypoxemia | Zendy

Tengyu Wang | Zendy; Davoud Eskandari | Zendy; Ding Zou | Zendy; Ludger Grote | Zendy; Jan Hedner | Zendy

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Increased Carbonic Anhydrase Activity is Associated with Sleep Apnea Severity and Related Hypoxemia

Author(s) -

Tengyu Wang,

Davoud Eskandari,

Ding Zou,

Ludger Grote,

Jan Hedner

Publication year - 2015

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.4814

Subject(s) - obstructive sleep apnea , hypoxemia , medicine , sleep apnea , blood pressure , endocrinology , polysomnography , body mass index , interquartile range , apnea , carbonic anhydrase , chemistry , biochemistry , enzyme

The catalytic function of the enzyme carbonic anhydrase (CA) plays a fundamental role in carbon dioxide (CO2), proton (H(+)), and bicarbonate (HCO3(-)) homeostasis. Hypoxia and tissue acidosis have been proposed to increase physiological CA activity in various compartments of the body. We hypothesized that CA activity in blood is upregulated in patients with obstructive sleep apnea (OSA).

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