Identification of Genes Associated with Resilience/Vulnerability to Sleep Deprivation and Starvation inDrosophila | Zendy

Matthew S. Thimgan | Zendy; Laurent Seugnet | Zendy; John Turk | Zendy; Paul J. Shaw | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Identification of Genes Associated with Resilience/Vulnerability to Sleep Deprivation and Starvation inDrosophila

Author(s) -

Matthew S. Thimgan,

Laurent Seugnet,

John Turk,

Paul J. Shaw

Publication year - 2015

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.4680

Subject(s) - sleep deprivation , starvation , vulnerability (computing) , gene , drosophila (subgenus) , identification (biology) , sleep (system call) , social deprivation , resilience (materials science) , genetics , biology , circadian rhythm , neuroscience , ecology , endocrinology , computer security , thermodynamics , physics , computer science , operating system , economic growth , economics

Flies mutant for the canonical clock protein cycle (cyc(01)) exhibit a sleep rebound that is ∼10 times larger than wild-type flies and die after only 10 h of sleep deprivation. Surprisingly, when starved, cyc(01) mutants can remain awake for 28 h without demonstrating negative outcomes. Thus, we hypothesized that identifying transcripts that are differentially regulated between waking induced by sleep deprivation and waking induced by starvation would identify genes that underlie the deleterious effects of sleep deprivation and/or protect flies from the negative consequences of waking.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research