Open AccessSex Dimorphism in Late Gestational Sleep Fragmentation and Metabolic Dysfunction in Offspring Mice
Author(s) -
Abdelnaby Khalyfa,
Alba Carreras,
Isaac Almendros,
Fahed Hakim,
David Gozal
Publication year - 2015
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.5665/sleep.4568
Subject(s) - offspring , endocrinology , medicine , adiponectin , leptin , biology , metabolic syndrome , adipokine , insulin resistance , sexual dimorphism , obesity , pregnancy , genetics
Excessive sleep fragmentation (SF) is common in pregnant women. Adult-onset metabolic disorders may begin during early development and exhibit substantial sex dimorphism. We hypothesized that metabolic dysfunction induced by gestational SF in male mice would not be apparent in female littermates.
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