Central and Peripheral Metabolic Changes Induced by Gamma-Hydroxybutyrate | Zendy

Gianina Luca | Zendy; Julie Vienne | Zendy; Angélique Vaucher | Zendy; Sònia Jiménez | Zendy; Mehdi Tafti | Zendy

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Central and Peripheral Metabolic Changes Induced by Gamma-Hydroxybutyrate

Author(s) -

Gianina Luca,

Julie Vienne,

Angélique Vaucher,

Sònia Jiménez,

Mehdi Tafti

Publication year - 2015

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.4420

Subject(s) - gamma hydroxybutyrate , endocrinology , medicine , pharmacology , biology

Gamma-hydroxybutyrate (GHB) was originally introduced as an anesthetic but was first abused by bodybuilders and then became a recreational or club drug.1 Sodium salt of GHB is currently used for the treatment of cataplexy in patients with narcolepsy. The mode of action and metabolism of GHB is not well understood. GHB stimulates growth hormone release in humans and induces weight loss in treated patients, suggesting an unexplored metabolic effect. In different experiments the effect of GHB administration on central (cerebral cortex) and peripheral (liver) biochemical processes involved in the metabolism of the drug, as well as the effects of the drug on metabolism, were evaluated in mice.

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