Open AccessHLA-DQ Allele Competition in Narcolepsy: A Comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe
Author(s) -
Hanna M. Ollila,
Marcelo Fernández-Viña,
Emmanuel Mignot
Publication year - 2014
Publication title -
sleep
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.222
H-Index - 207
eISSN - 1550-9109
pISSN - 0161-8105
DOI - 10.5665/sleep.4342
Subject(s) - narcolepsy , human leukocyte antigen , cataplexy , allele , locus (genetics) , genetics , hla dqb1 , medicine , biology , gene , psychiatry , antigen , neurology
Although HLA-DQB1*06:02 is the strongest predisposing genetic factor for narcolepsy, the effect of this gene must be considered alongside that of its polymorphic partner, DQA1. In this paper, we extend an analysis of the effect of HLA-DQB1 on narcolepsy risk published recently by Tafti et al.
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