Dexmedetomidine-Induced Sedation Does Not Mimic the Neurobehavioral Phenotypes of Sleep in Sprague Dawley Rat | Zendy

Abigail G. Garrity | Zendy; Simhadri Botta | Zendy; Stephanie B. Lazar | Zendy; Erin Swor | Zendy; Giancarlo Vanini | Zendy; Helen A. Baghdoyan | Zendy; Ralph Lydic | Zendy

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Dexmedetomidine-Induced Sedation Does Not Mimic the Neurobehavioral Phenotypes of Sleep in Sprague Dawley Rat

Author(s) -

Abigail G. Garrity,

Simhadri Botta,

Stephanie B. Lazar,

Erin Swor,

Giancarlo Vanini,

Helen A. Baghdoyan,

Ralph Lydic

Publication year - 2014

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.4328

Subject(s) - dexmedetomidine , sedation , non rapid eye movement sleep , anesthesia , sleep (system call) , medicine , psychology , rapid eye movement sleep , eye movement , neuroscience , computer science , operating system

Dexmedetomidine is used clinically to induce states of sedation that have been described as homologous to nonrapid eye movement (NREM) sleep. A better understanding of the similarities and differences between NREM sleep and dexmedetomidine-induced sedation is essential for efforts to clarify the relationship between these two states. This study tested the hypothesis that dexmedetomidine-induced sedation is homologous to sleep.

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