Sleep Deprivation Aggravates Median Nerve Injury-Induced Neuropathic Pain and Enhances Microglial Activation by Suppressing Melatonin Secretion | Zendy

ChunTa Huang | Zendy; Rayleigh PingYing Chiang | Zendy; Chih-Li Chen | Zendy; YiJu Tsai | Zendy

Open Access

Sleep Deprivation Aggravates Median Nerve Injury-Induced Neuropathic Pain and Enhances Microglial Activation by Suppressing Melatonin Secretion

Author(s) -

ChunTa Huang,

Rayleigh PingYing Chiang,

Chih-Li Chen,

YiJu Tsai

Publication year - 2014

Publication title -

sleep

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.222

H-Index - 207

eISSN - 1550-9109

pISSN - 0161-8105

DOI - 10.5665/sleep.4002

Subject(s) - melatonin , sleep deprivation , neuropathic pain , medicine , proinflammatory cytokine , endocrinology , microglia , anesthesia , circadian rhythm , inflammation

Sleep deprivation is common in patients with neuropathic pain, but the effect of sleep deprivation on pathological pain remains uncertain. This study investigated whether sleep deprivation aggravates neuropathic symptoms and enhances microglial activation in the cuneate nucleus (CN) in a median nerve chronic constriction injury (CCI) model. Also, we assessed if melatonin supplements during the sleep deprived period attenuates these effects.

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